Broad health care ETFs in the biology trade
Large drugmakers, insurers, hospitals and device makers together. Driven by what governments and insurers pay, and patent expiries at the largest drugmakers.
18ETFs in this category
$86.4bnmoney in them
66.4%of the biology trade’s money
XLVlargest unleveraged ETF, 56.6%
How they did, to Nov 2, 2026
| 1 month | YTD | 12 months | |
|---|---|---|---|
| Category median | +6.8% | +16.5% | +23.4% |
| Its story | +7.5% | +21.0% | +29.0% |
| Broad US ETFs | −2.5% | +11.5% | +11.8% |
Every ETF here, largest first
| # | ETF | Name | Assets | Share | 12 months | Fee |
|---|---|---|---|---|---|---|
| 1 | XLV | Health Care Select Sector SPDR Fund | $48.9bn | 56.6% | +30.1% | 0.08% |
| 2 | VHT | Vanguard Health Care ETF | $20.7bn | 24.0% | +28.3% | 0.09% |
| 3 | IYH | iShares US Healthcare ETF | $4.6bn | 5.4% | +29.1% | 0.37% |
| 4 | IXJ | iShares Global Healthcare ETF | $4.6bn | 5.3% | +25.4% | 0.38% |
| 5 | FHLC | Fidelity MSCI Health Care Index ETF | $3.9bn | 4.6% | +28.5% | 0.08% |
| 6 | FXH | First Trust Health Care AlphaDEX Fund | $1.2bn | 1.4% | +24.3% | 0.61% |
| 7 | RSPH | Invesco S&P 500 Equal Weight Health Care ETF | $992m | 1.1% | +32.8% | 0.40% |
| 8 | PINK | Simplify Health Care ETF | $336m | 0.4% | +21.0% | 0.51% |
| 9 | PTH | Invesco Dorsey Wright Healthcare Momentum ETF | $303m | 0.4% | +22.4% | 0.60% |
| 10 | XHS | State Street SPDR S&P Health Care Services ETF | $234m | 0.3% | +38.0% | 0.35% |
| 11 | PSCH | Invesco S&P SmallCap Health Care ETF | $182m | 0.2% | +30.7% | 0.29% |
| 12 | XHE | State Street SPDR S&P Health Care Equipment ETF | $157m | 0.2% | +16.1% | 0.35% |
| 13 | KURE | KraneShares MSCI All China Health Care Index ETF | $109m | 0.1% | −6.6% | 0.65% |
| 14 | MEDI | Harbor Health Care ETF | $46m | 0.1% | +16.9% | 0.80% |
| 15 | TMED | T. Rowe Price Health Care ETF | $35m | 0.0% | +19.9% | 0.44% |
| 16 | GDOC | Goldman Sachs Future Health Care Equity ETF | $21m | 0.0% | +14.0% | 0.75% |
| 17 | JDOC | Jpmorgan Healthcare Leaders ETF | $10m | 0.0% | +20.3% | 0.65% |
| 18 | IBRN | iShares Neuroscience and Healthcare ETF | $7m | 0.0% | +8.7% | 0.47% |
Other categories in the biology trade
Common questions
Which ETFs are broad health care ETFs?18 US ETFs sit in this category of the biology trade. Large drugmakers, insurers, hospitals and device makers together. Driven by what governments and insurers pay, and patent expiries at the largest drugmakers.
What is the largest broad health care ETF?XLV, Health Care Select Sector SPDR Fund, with $48.9bn, 56.6% of the category's money.
How have broad health care ETFs performed?The median unleveraged ETF here returned +23.4% over the last 12 months to Nov 2, 2026, against +11.8% for broad US ETFs. Past performance, not a forecast.